Trufanov G., Dergunova N., Boykov I.
Medicomilitary Academy, Saint Petersburg, Russia
The research goal was to study potentialities of combined PET and CT examination (PET-CT) in revealing and differential diagnosis of glial cerebral tumors.
Material and Methods. We examined 62 cases. The study was carried out with applying the Biograph PET-CT scanner (Siemens). All the patients underwent spiral CT with I/V bolus enhancement. Subsequent PET examination was carried out after administration of 150-200 MBq of 180-fluordeoxyglycose (FDG).
Results. The obtained data allowed to make a conclusion on presence of high-grade and low-grade glial tumors in 40 and 22
High-grade glial tumors (glioblasyomas, anaplastic astrocytomas) were characterized not only by a typical CT-picture, but also by some certain PET-signs: an area of extremely considerable accumulation of a radiopreparation in the brain substance, which was 4-6 times greater than normal indices. This area had loci of reduced glucose metabolism, corresponding to necrotic zones. Besides, it was surrounded by a zone of reduced accumulation, being a reflection of paratumorous edema.
PET-signs of low-grade glial tumors included an area of reduced or unchanged metabolism of 180-FDG. It was surrounded (especially in case of fibrillar astrocytoma) by a wide zone of low accumulation of a radiopreparation, corresponding to paratumorous edema.
Conclusion. Thus, one can conclude, that combined PET-CT examination is an up-to-date and highly informative method of radiodiagnosis, permitting to reveal and differentiate cerebral masses.