Use of DWI-MRT for Differential Diagnosis of Solitary Metastatic Tumors and Malignant Cerebral Gliomas

Dolgushin ., Pronin I., Fadeeva L., Serkov S., Kornienko V.

Burdenko Research Institute of Neurosurgery, Moscow, Russia

 

Oncologic diseases with the CNS lesions account for not less than 8% of all tumors. A one forth of them is represented by metastatic lesions and this figure continues to grow.

The goal of the present research was to estimate potentialities of DWI-MRT in metastatic lesions of the brain.

Material and Methods. Mean values of a measured diffusion coefficient (MDC) were as follows: the borderline zone of contrasting (1.27±0.2)´10-3 and (1.15±0.2)´10-3 mm2/s, the nearest peritumoral zone (1.51±0.1)´10-3 and (1.28±0.2)´10-3 mm2/s, a zone of vasogenic edema (1.51±0.3)´10-3 and (1.56±0.2)´10-3 mm2/s. MDC values, typical of the tumor borderline and peritumoral areas, were lower in patients with cancer metastases (p<0.15), as compared to cases with glioblastomas. There was correlation between MDC values in the nearest peritumoral zone and a peripheral zone of vasogenic edema in both groups (r=0.709538, p<0.05).

Conclusion. Thus, MCD values in a zone of edema are higher in 85% of cases with glioblastomas in comparison with patients with metastases. Is can be indicative of a greater content of water in zones of peritumoral edema around glioblastomas than in areas around metastatic tumor foci.