Dolgushin Ì., Pronin I., Fadeeva L., Serkov S., Kornienko V.
Burdenko Research Institute of Neurosurgery, Moscow, Russia
Oncologic diseases with the CNS lesions account for not less than 8% of all tumors. A one forth of them is represented by metastatic lesions and this figure continues to grow.
The goal of the present research was to estimate potentialities of DWI-MRT in metastatic lesions of the brain.
Material and Methods. Mean values of a measured diffusion coefficient (MDC) were as follows: the borderline zone of contrasting – (1.27±0.2)´10-3 and (1.15±0.2)´10-3 mm2/s, the nearest peritumoral zone – (1.51±0.1)´10-3 and (1.28±0.2)´10-3 mm2/s, a zone of vasogenic edema – (1.51±0.3)´10-3 and (1.56±0.2)´10-3 mm2/s. MDC values, typical of the tumor borderline and peritumoral areas, were lower in patients with cancer metastases (p<0.15), as compared to cases with glioblastomas. There was correlation between MDC values in the nearest peritumoral zone and a peripheral zone of vasogenic edema in both groups (r=0.709538, p<0.05).
Conclusion. Thus, MCD values in a zone of edema are higher in 85% of cases with glioblastomas in comparison with patients with metastases. Is can be indicative of a greater content of water in zones of peritumoral edema around glioblastomas than in areas around metastatic tumor foci.