A Degree of Malignancy of Cerebral Tumors: The Role of SPECT with 99mTc-MIBI

Dekan V., Trufanov G., Martinov B.

Medicomilitary Academy, Saint Petersburg, Russia


Malignant activity of cerebral tumor is one of the most important factors in determining disease prognosis.

The research goal was to estimate potentialities of SPECT with 99mTc-MIBI in determining signs of malignancy of primarily diagnosed cerebral tumors, assessing treatment efficacy and revealing further neoplasm growth.

Material and Methods. We examined 75 cases with intracerebral tumors, having a different histological structure. All of them were subject to MRI or CT and SPECT examinations. I/V administration of a radiopreparation in a dose of 500 MBq was followed by head scanning, which started in 60 min. The results were estimated visually and semi-qualitatively with calculation of relative coefficients of a radiopreparation accumulation within a pathologic focus. Comparison with intact cerebral tissue, located on the opposite side or adjacent to a tumor, was carried out.

Results. Glioblastomas were characterized by increased accumulation of a radiopreparation; their structure was heterogeneous and had uneven outlines; sometimes there were necrotic foci within a tumor. Anaplastic astrocytomas looked like a heterogeneous structure with high accumulation of a radiopreparation, which was 3-5 times greater in comparison with adjacent tissues. There was no increased accumulation of a radiopreparation in protoplasmatic astrocytomas. Metastases of pulmonary cancer were visualized as foci with considerably higher accumulation of a radiopreparation, which had a homogenous structure and distinct even outlines.

Conclusion. Thus, SPECT with 99mTc-technetril is an effective method of diagnosis of malignant cerebral tumors. It allows to carry out qualitative and semi-quantitative estimation of a pathologic mass character and to express an opinion on a possible degree of its malignancy.