Patients with Constrictive-Stenotic Arteriopathy Tolerant to Vasodilators: Results of Microscopic Studies of Arteries Located in a Zone of Hemorrhage due to Bifurcation Aneurysm Rupture

Yu.A. Medvedev, B.M. Nikiforov, Zh.Z. Zakaryavichus, V.P. Bersnev, Yu.M. Zabrodskaya

(Polenov Research Neurosurgical Institute, Saint Petersburg)

There were 30 cases, who died during the 2nd-4th weeks after ruptures of cerebral bifurcation aneurysms. The material (arteries) was taken from a zone of spasm, diagnosed with the help of angiography, when they had been alive.

Conventional methods of examination (optic and electron microscopy) were used.

It was found out, that during a period, characterized by absence of dilatation therapy effects, smooth-muscle cells of segments of Willis circle arteries had been in a parabiotic state (dystrophy) or dead (necrosis). The greatest changes were typical of a contraction apparatus of muscular cells (thin and thick myofibrils). It was either subject to irreversible changes or perished with formation of peculiar "onion" ball-like structures, seen in semi-thin sections even in light microscopy. A degenerative-necrotic process was caused by a superdurable irreversible spasm-contracture.