A Child's State and Its Dynamics after Neurotransplantation of Embryonal Nervous Tissue

Galanin I.V., Ovechko V.I., Shlepakov I.M., Shustin V.A.

(Bekhterev Research Psychoneurologic Institute Polenov Research Neurosurgical Institute)

Patient D., aged 5, was admitted to the Institute in October 1999 with the following diagnosis: retarded mental and speech development, marked syndrome of motor hyperactivity. There was asphyxia during labor. Development was normal till the age of five; then the child lost all acquired skills. Speech production reduced from short phrases to separate syllables. The child needed constant assistance. There was motor hyperactivity, sometimes reaching a level of aggressiveness. Mental and speech development corresponded to the age of 1-1.5. All games were of a destructive character. The child was treated in hospitals (7 admissions) and outpatient departments since he was 1.5. There was no effect. He needed constant assistance and care.

The patient was operated on October 7, 1999. The operation consisted in transplantation of embryonal nervous tissue into the cortex of the frontotemporal area on the left and the frontal area on the right. It was done through a trephination hole. There was gradual improvement of the patient's state. Syndrome of motor hyperactivity almost regressed in December of this year, i.e. 14 months after the operation. The child began to dress, eat, make a bed, etc. himself. He fulfills tasks at the level of the lower border of age standards. His vocabulary is ten times larger. The child is kept at home; he can play without any assistance. His ability to study is much better. A number of orders, fulfilled correctly, exceeds 120.

The demonstration goal:

To show efficacy of transplantation of embryonal nervous tissue in such disorders.