A.A. Potapov, G.G. Shaginyan, I.A. Aleksandrova, V.F. Imshenetskaya, A.D. Kravchuk, L.B. Likhterman

Burdenko Research Institute of Neurosurgery

Tactics of surgical and conservative treatment as well as types of species, their structure and resistance of infecting agents responsible for pyo-inflammatory complications to antibiotics are analyzed in 193 cases with penetrating gunshot craniocerebral wounds who were admitted to Burdenko Research Institute of Neurosurgery in October 1993-December 1998.

All the wounded underwent complex examination including CT of the brain on admission and during treatment. Bacteriologic study of lumbar and ventricular liquor, fluid accumulating under a skin graft, abscess content, bone fragments, discharge from wounds and fistulas was carried out. Resistance to antibiotics was determined on the basis of one out of three programs and a set of disks with 15 antibacterial drugs for Gram-positive, Gram-negative and non-fermenting bacteria.

Data on the structure and resistance of infecting agents causing posttraumatic pyo-inflammatory complications to antibiotics and results of treatment were used for determination of the most effective scheme of antibiotic treatment.